Achtung: Zufahrt geändert zum Campus Barmen

Aufgrund der Vollsperrung der Schönebecker Straße ist die Zufahrt zum Klinikum für den Auto- und Busverkehr geändert. Bitte beachten Sie die Schilder!

Kai O. Hensel
Prof. Dr. med.
Kai O. Hensel
Direktor des Zentrums für Kinder- und Jugendmedizin

Außerdem: Facharzt für Kinderheilkunde, Zusatzbezeichnung „Kinder-Gastroenterologie”, Zertifizierung „GPGE-Gastroenterologie”, Schwerpunktbezeichnung „Neonatologie”, Qualifikation „Neugeborenen-Notarzt” (GNPI), Zusatzbezeichnung „Notfallmedizin”, PhD-Programm „Biomedizin”, Creator & Host des Pädiatrie-Podcasts „Die Expertise-Piraten

Helios Universitätsklinikum Wuppertal - Campus Barmen
Heusnerstraße 40
42283 Wuppertal
Tel: (0202) 896-3831
Fax: (0202) 896-3834
Meine Fachbereiche

Kinder- und Jugendmedizin


  • Facharzt für Kinder- und Jugendmedizin
  • Zusatzbezeichnung „Kinder-Gastroenterologie”
    Zertifizierung „GPGE-Gastroenterologie”
  • Schwerpunktbezeichnung „Neonatologie”
    Qualifikation „Neugeborenen-Notarzt” (GNPI)
  • Diabetologe DDG
  • Zusatzbezeichnung „Notfallmedizin”
  • PhD-Programm „Biomedizin”
  • Creator & Host des Pädiatrie-Podcasts „Die Expertise-Piraten




Universitätsklinikum Wuppertal, Zentrum für Kinder- und Jugendmedizin

 Professur für
klinische Pädiatrie

Universität Witten/Herdecke, Lehrstuhl für Pädiatrie



Universitätsmedizin Göttingen, Klinik für Kinderkardiologie und Intensivmedizin


Oberarzt /(Senior) Clinical Fellow

University of Cambridge, Addenbrooke‘s Hospital, Department of Paediatric Gastroenterology, Hepatology & Nutrition

07/2016-09/2017NotarztHelios Universitätsklinikum Wuppertal, Rettungsdienst

Assistenzarzt in Weiterbildung

Helios Universitätsklinikum Wuppertal, Zentrum für Kinder- und Jugendheilkunde



im Fach Pädiatrie - Universität Witten/Herdecke

Thema: ”Advanced Echocardiography Techniques for the Detection of Subclinical Myocardial Dysfunction in Patients with Chronic Disorders and no Structural Heart Disease”


Promotion „PhD“ - magna cum laude

Universität Witten/Herdecke

Thema: ”Host Epigenetic Signature Response and Functional Nuclear Architecture in Hepatitis B Virus Infections”


Promotion „Dr. med.“- magna cum laude

Universität Witten/Herdecke

Thema: “Speckle-Tracking Stress Echocardiography in Arterial Hypertension and Healthy Volunteers”

Grundlagen- und translationale Forschung

  • Edgar R., et al., Hensel K.O., et al.: Culture Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids. Cellular and Molecular Gastroenterology and Hepatology S2352-345X(22)00186-2 (2022)
  • Hensel K.O., et al.: Virus-host interplay of HBV and host nuclear architecture: HBx and cccDNA localize in nuclear regions of open chromatin and active gene transcription. Epigenetics and Chromatin 22;11(1):34 (2018)
  • Hensel K.O. et al.: Virus-host-interplay in hepatitis B virus infection and epigenetic treatment strategies. FEBS Journal 284(21):3550- 3572 (2017)
  • Weil P.P., Hensel K.O., et al.: An expanding universe of noncoding RNAs between the poles of basic science and clinical investigations. Epigenomics 8(3):317-9 (2016)
  • Willems R., Krych L., Rybicki V., Jiang P., Sangild PT., Shen R.L., Hensel K.O., et al.: Introducing enteral feeding induces intestinal subclinical inflammation and respective chromatin changes in preterm pigs. Epigenomics 7(4):553-65 (2015)
  • Postberg J., Kanders M., Forcob S., Willems R., Orth V., Hensel K.O., et al.: CpG signaling, H2A.Z/H3 acetylation and miRNA mediated deferred self-attenuation orchestrate foetal NOS3 expression. Clinical Epigenetics 7, 9 (2015)
  • Hensel K.O., et al.: Differential expression of mucosal trefoil factors und mucins in paediatric inflammatory bowel diseases. Scientific reports 4, 7343 (2014)
  • Hensel K.O. et al.: Restitution of hepatitis b virus-manipulated gene expression and plastic chromatin deformation in non-transformed murine hepatocytes. Clinical Epigenetics 6, 26 (2014)

Klinische Forschung

  • Dieks J., Jünemann L., Hensel K.O., et al.: Stereophotogrammetry can feasibly assess ‘physiological’ longitudinal three-dimensional head development of very preterm infants from birth to term. Scientific Reports 27;12(1):8940 (2022)
  • Köchling J., Geis B., Chao C., Dieks J., Wirth S., Hensel K.O.: The hazardous (mis)perception of Self-estimated Alcohol intoxication and Fitness to drivE – an avoidable health risk: the SAFE randomised trial. Harm Reduction Journal doi: 10.1186/s12954-021-00567-4 (2021)
  • Dieks J., Hensel K.O., et al.: Stereophotogrammetric head shape assessment in neonates is feasible and can identify distinct differences between term-born and very preterm infants at term equivalent age. Scientific Reports doi: 10.1038/s41598-021-00680-1 (2021)
  • Samyn M., Hensel K.O. et al.: Letter to the editor: reply. Journal of Pediatrics doi: 10.1016/j.jpeds.2021.09.011 (2021)
  • Hensel K.O., et al.: Sclerosing cholangitis in pediatric inflammatory bowel disease - early diagnosis and management affect clinical outcome. Journal of Pediatrics doi: 10.1016/j.jpeds.2021.07.047 (2021)
  • Orfei M., Gasparetto M., Hensel K.O., et al.: Guidance on the interpretation of faecal calprotectin levels in children. PLoS ONE 16(2): e0246091 (2021)
  • Verster J.C., et al, Hensel K.O., et al.: Sensitivity to Experiencing Alcohol Hangovers: Reconsideration of the 0.11% Blood Alcohol Concentration (BAC) Threshold for Having a Hangover. Journal of Clinical Medicine 9;9(1) (2020)
  • Hensel K. O.: Time to shape up – assessment and reporting standards for data quality in clinical research using echocardiographic imaging techniques require improvement. BMC Cardiovascular Disorders 19:281 (2019)
  • Hensel K.O., Longmire M., Köchling J.: Should population-based research steer individual health decisions? Aging (Albany) 11(21): 9231–9233 (2019)
  • Köchling J., Geis B., Wirth S., Hensel K.O.: Grape or grain but never the twain? A randomized controlled multiarm matched-triplet crossover trial of beer and wine. American Journal of Clinical Nutrition 109(2):345-352 (2019)
  • Wilke L., Abellan Schneyder F., Roskopf M., Jenke A., Heusch A., Hensel K.O.: Speckle tracking stress echocardiography in children: interobserver and intraobserver reproducibility and the impact of echocardiographic image quality. Scientific Reports 8(1):9185 (2018)
  • Hensel K.O.: Subclinical left ventricular systolic and diastolic dysfunction in type 1 diabetic children and adolescents with good metabolic control. Echocardiography. 35(4):578-579 (2018)
  • Hensel K.O., Roskopf M., Abellan Schneyder F., Heusch A.: Novel functional advanced echocardiography for the assessment of myocardial mechanics in children with neurocardiogenic syncope - a blinded prospective speckle tracking head-up tilt-table challenge study. BMC Cardiovascular Disorders 8;18(1):87 (2018)
  • Hensel K.O., Roskopf M., Wilke L., Heusch A.: Intraobserver and interobserver reproducibility of m-mode and b-mode acquired mitral annular plane systolic excursion (MAPSE) and its dependency on echocardiographic image quality in children. PLOS One 10;13(5):e0196614 (2018)
  • Hensel K.O., et al.: Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Disease. Scientific Reports 7:2966 (2017)
  • Hensel K.O., et al.: Nursing staff fluctuation and pathogenic burden in the NICU - effective outbreak management and the underestimated relevance of non-resistant strains. Scientific Reports 21;7:45014 (2017)
  • Hensel K.O., Wilke L., Heusch A.: Transthoracic speckle tracking echocardiography for the quantitative assessment of left ventricular myocardial deformation. Journal of Visualized Experiments 116, e54736 (2016)
  • Hensel K.O.: Non-ischemic diabetic cardiomyopathy may initially exhibit a transient subclinical phase of hyperdynamic myocardial performance. Medical Hypotheses 94:7-10 (2016)
  • Hensel K.O., et al.: Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus – a Prospective Blinded Speckle Tracking Stress Echocardiography Study. Journal of Diabetes Research 2016:2583747 (2016)
  • Hensel K.O., et al.: The Influence of Real-Time Blood Glucose Levels on Left Ventricular Myocardial Strain and Strain Rate in Pediatric Patients with Type 1 Diabetes Mellitus. BMC Cardiovascular Disorders 15(1):175 (2015)
  • Leischik R., Dworrak B., Hensel K.O.: Intraobserver and interobserver reproducibility for radial, circumferential and longitudinal strain echocardiography. Open cardiovascular medicine journal 8, 102-109 (2014)
  • Hensel K.O., Jenke A., Leischik R.: Speckle-tracking and tissue-doppler stress echocardiography in arterial hypertension - a sensitive tool for detection of subclinical LV impairment. BioMed research international 2014:9 (2014)
  • Wirth S., Klodt C., Wintermeyer P., Berrang J., Hensel K., et al.: Positive or Negative Fructose Breath Test Results do not Predict Response to Fructose Restricted Diet in Children with Recurrent Abdominal Pain: Results from a Prospective Randomized Trial. Klinische Pädiatrie 226(5), 268-273 (2014)
  • Wirth S., Bortolotti F., Brunert C., Postberg J., Hensel K., et al.: Hepatitis b virus genotype change in children is closely related to HBeag/anti-HBe seroconversion. Journal of pediatric gastroenterology and nutrition 57, 363-366 (2013)
  • Jenke A.C., Postberg J., Mariel B., Hensel K., et al.: S100a12 and hbd2 correlate with the composition of the fecal microflora in elbw infants and expansion of e. Coli is associated with nec. BioMed research international 150372 (2013)


  • Degener S, Dürbeck M., Roth S., Wirth S., Hensel K.O.: Are parents informed well enough about their child’s long-term risks related to undescended testis? Indian Pediatrics 15;59(3):252-253 (2022)
  • Hensel K.O., Powell J: Viewpoint: Digital paediatrics – so close yet so far away. Archives of Disease in Childhood doi: 10.1136/archdischild-2021-322719 (2022)
  • Hensel K.O.: The double-edged sword of limiting healthcare provision for children in times of covid: the hidden price we pay. Archives of Disease in Childhood 106(7):e29 (2021)
  • Böhme P., Degener S., Wirth S., Geis B., Aydin M., Lawrenz K., Tröbs R., Schmittenbecher P., Beume J., Pötzsch S., Schwarz B., Hensel K.O.: Multicenter Analysis of Acquired Undescended Testis and Its Impact on the Timing of Orchidopexy. Journal of Pediatrics 223:170- 177.e3 (2020)
  • Hansen A., Herrmann M., Ehlers J., Mondritzki T., Hensel K.O., et al.: Perception of the Progressing Digitization and Transformation of the German Health Care System Among Experts and the Public: Mixed Methods Study. JMIR Public Health and Surveillance 5(4):14689 (2019)
  • Aydin M., Niggeschmidt J., Ballauf A., Wirth S., Hensel K.O.: Common indications and the diagnostic yield of esophagogastroduodenoscopy in children with gastrointestinal distress. Klinische Pädiatrie 231(1):21-27 (2019)
  • Zamrik S., Giachero F., Heldmann M., Hensel K.O., et al.: Impact of an in-house pediatric surgery unit and human milk centered enteral nutrition on necrotizing enterocolitis. BioMed research international 5042707 (2018)
  • Böhme P., Geis B., Dörner J., Wirth S., Hensel K.O.: Shortcomings in the management of undescended testis: guideline intention vs. reality and the underlying causes – insights from the biggest German cohort. British Journal of Urology International 122(4):644-653 (2018) – (declared article of the week)
  • Heusch A.., Kahl H.J., Hensel K.O., Calaminus G.: Health-related quality of life in paediatric patients with congenital heart defects: association with the type of heart defect and the surgical technique. Quality of Life Research 26(11):3111-3117 (2017)
  • Hensel K.O., et al.: Operative Management of Cryptorchidism: Guidelines and Reality - a 10-Year Observational Analysis of 3587 Cases. BMC Pediatrics 15(1):116 (2015)
  • Reith G., Lefering R., Wafaisade A., Hensel K.O., et al.: Injury pattern, outcome and characteristics of severely injured pedestrians. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 23:56 (2015)
  • Reith G., Schmitz-Greven V., Hensel K.O., et al.: Metal implant removal: Benefits and drawbacks – a patient survey. BMC Surgery 15:96 (2015)
  • Hensel K.O., Wirth S.: Current shortcomings in the treatment of cryptorchidism – analysis of a pediatrician. Aktuelle Urologie 46(5):373-377 (2015)
  • Hensel K.O., Wirth S.: Undescended testis guideline — is it being implemented in practice? Deutsches Ärzteblatt International 111, 647–8 (2014)
Helios Universitätsklinikum Wuppertal - Campus Barmen
Heusnerstraße 40
42283 Wuppertal