Forschung in der Klinischen Pharmakologie

Family Conferences to Facilitate Deprescribing in Older Outpatients With Frailty and With Polypharmacy: The COFRAIL Cluster Randomized Trial.
Mortsiefer A, Löscher S, Pashutina Y, Santos S, Altiner A, Drewelow E, Ritzke M, Wollny A, Thürmann P, Bencheva V, Gogolin M, Meyer G, Abraham J, Fleischer S, Icks A, Montalbo J, Wiese B, Wilm S, Feldmeier G.
JAMA Netw Open. 2023 Mar 1;6(3):e234723. doi: 10.1001/jamanetworkopen.2023.4723.
PMID: 36972052 

Potentially Inadequate Medications in the Elderly: PRISCUS 2.0—First Update of the PRISCUS List.
Mann NK, Mathes T, Sönnichsen A, Pieper D, Klager E, Moussa M, Thürmann PA.
Dtsch Arztebl Int. 2023 Jan 9;120(Forthcoming):3-10. doi: 10.3238/arztebl.m2022.0377. Online ahead of print.
PMID: 36507719 

Development of a deprescribing manual for frail older people for use in the COFRAIL study and in primary care.
Mann NK, Schmiedl S, Mortsiefer A, Bencheva V, Löscher S, Ritzke M, Drewelow E, Feldmeier G, Santos S, Wilm S, Thürmann PA; COFRAIL study group.
Ther Adv Drug Saf. 2022 Sep 6;13:20420986221122684. doi: 10.1177/20420986221122684. eCollection 2022.
PMID: 36091625 

Assessing the quality of evidence on safety: specifications for application and suggestions for adaptions of the GRADE-criteria in the context of preparing a list of potentially inappropriate medications for older adults.

Mathes T, Mann NK, Thürmann P, Sönnichsen A, Pieper D.
BMC Med Res Methodol. 2022 Aug 30;22(1):234. doi: 10.1186/s12874-022-01715-5.
PMID: 36042413

HIOPP-6 - a pilot study on the evaluation of an electronic tool to assess and reduce the complexity of drug treatment considering patients' views.

Wurmbach VS, Schmidt SJ, Lampert A, Bernard S, Meid AD, Frick E, Metzner M, Wilm S, Mortsiefer A, Bücker B, Altiner A, Sparenberg L, Szecsenyi J, Peters-Klimm F, Kaufmann-Kolle P, Thürmann PA, Seidling HM, Haefeli WE.
BMC Prim Care. 2022 Jun 28;23(1):164. doi: 10.1186/s12875-022-01757-0.
PMID: 35764923

A review found heterogeneous approaches and insufficient reporting in overviews on adverse events.
Sachse T, Mathes T, Dorando E, Heß S, Thürmann P, Schmiedl S, Kanji S, Lunny C, Thabet P, Pieper D.
J Clin Epidemiol. 2022 Nov;151:104-112. doi: 10.1016/j.jclinepi.2022.08.004. Epub 2022 Aug 17.
PMID: 35987405

Adherence to Direct Oral Anticoagulants in Patients With Non-Valvular Atrial Fibrillation: A Cross-National Comparison in Six European Countries (2008-2015).
Sabaté M, Vidal X, Ballarin E, Rottenkolber M, Schmiedl S, Grave B, Huerta C, Martin-Merino E, Montero D, Leon-Muñoz LM, Gasse C, Moore N, Droz C, Lassalle R, Aakjær M, Andersen M, De Bruin ML, Souverein P, Klungel OH, Gardarsdottir H, Ibáñez L.
Front Pharmacol. 2021 Nov 3;12:682890. doi: 10.3389/fphar.2021.682890. eCollection 2021.
PMID: 34803665 

A patient-centred web-based adverse drug reaction reporting system identifies not yet labelled potential safety issues.
Hasford J, Bruchmann F, Lutz M, Thürmann P, Schmiedl S.
Eur J Clin Pharmacol. 2021 Nov;77(11):1697-1704. doi: 10.1007/s00228-021-03134-9. Epub 2021 Jun 18.
PMID: 34143228 

Comparing Predictions of a PBPK Model for Cyclosporine With Drug Levels From Therapeutic Drug Monitoring.
Zapke SE, Willmann S, Grebe SO, Menke K, Thürmann PA, Schmiedl S.
Front Pharmacol. 2021 May 14;12:630904. doi: 10.3389/fphar.2021.630904. eCollection 2021.
PMID: 34054518

Loxapine for Treatment of Patients With Refractory, Chemotherapy-Induced Neuropathic Pain: A Prematurely Terminated Pilot Study Showing Efficacy But Limited Tolerability.
Schmiedl S, Peters D, Schmalz O, Mielke A, Rossmanith T, Diop S, Piefke M, Thürmann P, Schmidtko A.
Front Pharmacol. 2019 Jul 25;10:838. doi: 10.3389/fphar.2019.00838. eCollection 2019.
PMID: 31402867