Chefarzt Prof. Dr. med. Markus Ruhnke

Publikationen 2012 - 2020

(vor 2012 siehe


ECIL-3 classical diagnostic procedures for the diagnosis of invasive fungal diseases in patients with leukaemia.

Arendrup MC, Bille J, Dannaoui E, Ruhnke M, Heussel CP, Kibbler C.  Bone Marrow Transplant 2012 Jan 9.


Safety and Tolerability of Voriconazole in Patients with Baseline Renal Insufficiency and Candidemia.

Oude Lashof AM, Sobel JD, Ruhnke M, Pappas PG, Viscoli C, Schlamm HT, et al. Antimicrob Agents Chemother 2012 Mar 26


Interlaboratory comparison of PCR-based identification of Candida and Aspergillus DNA in spiked blood samples.

Reichard U, Buchheidt D, Lass-Florl C, Loeffler J, Lugert R, Ruhnke M, et al. Mycoses 2012 Jan 16.


Diagnosis of invasive fungal infections in hematology and oncology--guidelines from the Infectious Diseases Working Party in Haematology and Oncology of the German Society for Haematology and Oncology (AGIHO).

Ruhnke M, Bohme A, Buchheidt D, Cornely O, Donhuijsen K, Einsele H, et al. Ann Oncol 2012 Apr;23(4):823-33.


Anidulafungin for the treatment of candidaemia/invasive candidiasis in selected critically ill patients. 

Ruhnke M, Paiva JA, Meersseman W, Pachl J, Grigoras I, Sganga G, et al.. Clin Microbiol Infect 2012 Jul;18(7):680-7.


Aspergillus in the Intensive Care Unit.

Ruhnke M, Kujath P, Vogelaers D. Current Fungal Infection Reports 2012 Jan 10;6(1, March 2012).


Species and susceptibility distribution of 1062 clinical yeast isolates to azoles, echinocandins, flucytosine and amphotericin B from a multi-centre study. 

Schmalreck AF, Willinger B, Haase G, Blum G, Lass-Flörl C, Fegeler W, Ruhnke, M. et al. Mycoses 2012 May;55(3):e124-e137.


Doxorubicin selects for fluconazole-resistant petite mutants in Candida glabrata isolates. 

Schulz B, Knobloch M, Weber K, Ruhnke M. Int J Med Microbiol 2012 Jul;302(3):155-61.


Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis. 

Schulz B, Knobloch M, Moran GP, Weber K, Ruhnke M. Med Mycol 2012 May;50(4):421-6.


Antimicrobial therapy of febrile complications after high-dose chemotherapy and autologous hematopoietic stem cell transplantation--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). 

Weissinger F, Auner HW, Bertz H, Buchheidt D, Cornely OA, Egerer G, Ruhnke, M. et al. Ann Hematol 2012 Aug;91(8):1161-74.


Efficacy and safety of anidulafungin in elderly, critically ill patients with invasive Candida infections: a post hoc analysis.

Dimopoulos G, Paiva JA,Meersseman W, Pachl J, Griogras I, Sganga G, Montravers P, Auzinger G, Sá MB, Miller PJ, Marcek T, Kantecki M, Ruhnke M. Int J Antimicrob Agents 2012 Dec, 40 (6):521-6.


de Witt M, Ortner P, Lipp HP, Sehouli J, Untch M, Ruhnke M, et al. Management of cytotoxic extravasation - ASORS expert opinion for diagnosis, prevention and treatment. Onkologie 2013;36(3):127-35.


Pharmacokinetics of anidulafungin in critically ill patients with candidemia/invasive candidiasis. 

Liu P, Ruhnke M, Meersseman W, Paiva JA, Kantecki M, Damle B. Antimicrob Agents Chemother 2013 Apr;57(4):1672-6


Immediate versus deferred empirical antifungal (IDEA) therapy in high-risk patients with febrile neutropenia: a randomized, double-blind, placebo-controlled, multicenter study. 

Maschmeyer G, Heinz WJ, Hertenstein B, Horst HA, Requadt C, Wagner T, Ruhnke, M. et al. Eur J Clin Microbiol Infect Dis 2013 May;32(5):679-89.


Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).

Mousset S, Buchheidt D, Heinz W, Ruhnke M, Cornely OA, Egerer G, et al. Ann Hematol 2013 Sep 12.


The challenge of systemic Candida infections. Hospital Infectious Diseases Europe.

Ruhnke M, Mikolajewska A. ebook link 2013;Autumn:8-11.


Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG/OAG) (AWMF 055/066).

Thoden J, Potthoff A, Bogner JR, Brockmeyer NH, Esser S, Grabmeier-Pfistershammer K, Ruhnke, M. et al. Infection 2013 Sep;41 Suppl 2:S91-115.


Central venous catheter-related infections in hematology and oncology: 2012 updated guidelines on diagnosis, management and prevention by the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology.

Hentrich M, Schalk E, Schmidt-Hieber M, Chaberny I, Mousset S, Buchheidt D, Ruhnke, M. et al. Ann Oncol 2014 May;25(5):936-47


Antifungal stewardship in invasive Candida infections.

Ruhnke M.  Clin Microbiol. Infect. 2014 Mar 24.


Primary Prophylaxis of Invasive Fungal Infections in Patients with Haematologic Malignancies. 2014 Update of the Recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. 

Tacke D, Buchheidt D, Karthaus M, Krause SW, Maschmeyer G, Neumann S, Ruhnke, M. et al.Ann Hematol. 2014 Sep;93(9):1449-56


Diagnosis and Antimicrobial Therapy of Lung Infiltrates in Febrile Neutropenic Patients (allogeneic SCT excluded) Updated Guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Oncology.

Maschmeyer G, Carratala J, Buchheidt D, Hamprecht A, Heussel CP, Kahl C, Ruhnke, M. et al. Ann Oncol. 2015 Jan;26(1):21-33.


Infection control issues relating to haematological malignancies in the era of multidrug-resistant bacterial pathogens. 

Ruhnke M, Arnold R, Gastmeier P. Lancet Oncol. 2014 Dec;15(13):e606-19.


Randomised, multicentre trial of micafungin vs. an institutional standard regimen for salvage treatment of invasive aspergillosis. 

Cornely OA, Meems L, Herbrecht R, Viscoli C, van Amsterdam RG, Ruhnke M. Mycoses. 2015 Jan;58(1):58-64.


Invasive Candida infections in surgical patients in intensive care units: a prospective, multicentre survey initiated by the European Confederation of Medical Mycology (ECMM) (2006-2008).

Klingspor L, Tortorano AM, Peman J, Willinger B, Hamal P, Sendid B, Velegraki A, Kibbler C, Meis JF, Sabino R, Ruhnke M, Arikan-Akdagli S, Salonen J, Dóczi I. Clin Microbiol Infect. 2015 Jan;21(1):87.e1-87


Estimated burden of fungal infections in Germany.

Ruhnke M, Groll AH, Mayser P, Ullmann AJ, Mendling W, Hof H, Denning DW; University of Manchester in association with the LIFE program. Mycoses. 2015 Oct;58 Suppl 5:22-8.


Determining the analytical specificity of PCR-based assays for the diagnosis of IA: What is Aspergillus?

Morton CO, White PL, Barnes RA, Klingspor L, Cuenca-Estrella M, Lagrou K, Bretagne S, Melchers W, Mengoli C, Caliendo AM, Cogliati M, Debets-Ossenkopp Y, Gorton R, Hagen F, Halliday C, Hamal P, Harvey-Wood K, Jaton K, Johnson G, Kidd S, Lengerova M, Lass-Florl C, Linton C, Millon L, Morrissey CO, Paholcsek M, Talento AF, Ruhnke M, Willinger B, Donnelly JP, Loeffler J; EAPCRI.  Med Mycol. 2016 Oct 7.


Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia.

Hahn-Ast C, Felder L, Mayer K, Mückter S, Ruhnke M, Hein R, Hellmich M, Schwab K, Rachow T, Brossart P, von Lilienfeld-Toal M.  Ann Hematol. 2016 May;95(6):1001-9.


CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation)-Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).

Schmidt-Hieber M, Silling G, Schalk E, Heinz W, Panse J, Penack O, Christopeit M, Buchheidt D, Meyding-Lamadé U, Hähnel S, Wolf HH, Ruhnke M, Schwartz S, Maschmeyer G.: Ann Oncol. 2016 Jul;27(7):1207-25


Recent developments in the management of invasive fungal infections in patients with oncohematological diseases.

Ruhnke M, Schwartz S.  Ther Adv Hematol. 2016 Dec;7(6):345-359.


Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia: the SEPIA Study.

Koehler P, Hamprecht A, Bader O, Bekeredjian-Ding I, Buchheidt D, Doelken G, Elias J, Haase G, Hahn-Ast C, Karthaus M, Kekulé A, Keller P, Kiehl M, Krause SW, Krämer C, Neumann S, Rohde H, La Rosée P, Ruhnke M, Schafhausen P, Schalk E, Schulz K, Schwartz S, Silling G, Staib P, Ullmann A, Vergoulidou M, Weber T, Cornely OA, Vehreschild MJ.: Int J Antimicrob Agents. 2017 Feb;49(2):218-223.


Kramer A, Pochhammer J, Walger P, Seifert U, Ruhnke M, Harnoss JC. [Spectrum of pathogens in postoperative complications of visceral surgery : The problem of multidrug resistance]. Chirurg 2017 May;88(5):369-76.


Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).

Heinz WJ, Buchheidt D, Christopeit M, von Lilienfeld-Toal M, Cornely OA, Einsele H, Ruhnke, M. et al. Ann Hematol 2017 Aug 30.


Prospective evaluation of the SeptiFAST multiplex real-time PCR assay for surveillance and diagnosis of infections in haematological patients after allogeneic stem cell transplantation compared to routine microbiological assays and an in-house real-time PCR method.

Elges S, Arnold R, Liesenfeld O, Kofla G, Mikolajewska A, Schwartz S, Ruhnke, M. et al.. Mycoses 2017 Sep 19.


Advances in the diagnosis and treatment of fungal infections of the CNS.

Schwartz S, Kontoyiannis DP, Harrison T, Ruhnke M.. Lancet Neurol 2018 Feb 21.


Efficacy of micafungin for the treatment of invasive candidiasis and candidaemia in patients with neutropenia.

Chandrasekar P, Sirohi B, Seibel NL, Hsu JW, Azie N, Wu C, Ruhnke, M. et al. Mycoses 2018 May;61(5):331-6.


Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).

Mellinghoff SC, Panse J, Alakel N, Behre G, Buchheidt D, Christopeit M, Ruhnke, M. et al. Ann Hematol 2018 Feb;97(2):197-207.


Siehl JM, Griesinger F, Hentrich M, Hoffmann C, Oette M, Ruhnke M, et al. HIV-assoziierte Lungenkarzinome.  2018.


Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Ruhnke, M. et al. Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38.


Diagnosis of Invasive Fungal Diseases in Haematology and Oncology. 2018 Update of the Recommendations of the Infectious Diseases Working Party of the German Society for Hematology and Medical Oncology (AGIHO).

Ruhnke M, Behre G, Buchheidt D, Christopeit M, Hamprecht A, Heinz W, et al. Mycoses 2018, Nov;61(11):796-813


Comment on: T2Candida MR as a predictor of outcome in patients with suspected invasive candidiasis starting empirical antifungal treatment: a prospective pilot study.

White PL, Barnes RA, Gorton R, Cruciani M, Loeffler J. Fungal  PCR Iniative (Working Group of the International Society of Human and Animal Mycology; J Antimicrob Chemother 2018 Aug 10.


Ruhnke M, Behre G, Buchheidt D, Christopeit M, Hamprecht A, Heinz W, et al. Invasive Pilzinfektionen – Diagnostik.  2019


Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.

Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, Clancy CJ, Wingard JR, Lockhart SR, Groll AH, Sorrell TC, Bassetti M, Akan H, Alexander BD, Andes D, Azoulay E, Bialek R, Bradsher RW, Bretagne S, Calandra T, Caliendo AM, Castagnola E, Cruciani M, Cuenca-Estrella M, Decker CF, Desai SR, Fisher B, Harrison T, Heussel CP, Jensen HE, Kibbler CC, Kontoyiannis DP, Kullberg BJ, Lagrou K, Lamoth F, Lehrnbecher T, Loeffler J, Lortholary O, Maertens J, Marchetti O, Marr KA, Masur H, Meis JF, Morrisey CO, Nucci M, Ostrosky-Zeichner L, Pagano L, Patterson TF, Perfect JR, Racil Z, Roilides E, Ruhnke M, Prokop CS, Shoham S, Slavin MA, Stevens DA, Thompson GR, Vazquez JA, Viscoli C, Walsh TJ, Warris A, Wheat LJ, White PL, Zaoutis TE, Pappas PG. Clin Infect Dis 2019 Dec 5.


Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. 

Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, Hoenigl M, Jensen HE, Lagrou K, Lewis RE, Mellinghoff SC, Mer M, Pana ZD, Seidel D, Sheppard DC, Wahba R, Akova M, Alanio A, Al-Hatmi AMS, Arikan-Akdagli S, Badali H, Ben-Ami R, Bonifaz A, Bretagne S, Castagnola E, Chayakulkeeree M, Colombo AL, Corzo-León DE, Drgona L, Groll AH, Guinea J, Heussel CP, Ibrahim AS, Kanj SS, Klimko N, Lackner M, Lamoth F, Lanternier F, Lass-Floerl C, Lee DG, Lehrnbecher T, Lmimouni BE, Mares M, Maschmeyer G, Meis JF, Meletiadis J, Morrissey CO, Nucci M, Oladele R, Pagano L, Pasqualotto A, Patel A, Racil Z, Richardson M, Roilides E, Ruhnke M, Seyedmousavi S, Sidharthan N, Singh N, Sinko J, Skiada A, Slavin M, Soman R, Spellberg B, Steinbach W, Tan BH, Ullmann AJ, Vehreschild JJ, Vehreschild MJGT, Walsh TJ, White PL, Wiederhold NP, Zaoutis T, Chakrabarti A; Mucormycosis ECMM MSG Global Guideline Writing Group.  Lancet Infect Dis. 2019 Dec;19(12):e405-e421. doi: 10.1016/S1473-3099(19)30312-3. Epub 2019 Nov 5. Review


Treatment of invasive fungal diseases in cancer patients - Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). 

Ruhnke M, Cornely OA, Schmidt-Hieber M, Alakel N, Boell B, Buchheidt D, Christopeit M, Hasenkamp J, Heinz WJ, Hentrich M, Karthaus M, Koldehoff M, Maschmeyer G, Panse J, Penack O, Schleicher J, Teschner D, Ullmann AJ, Vehreschild M, von Lilienfeld-Toal M, Weissinger F, Schwartz S.  Mycoses. 2020 Mar 31. doi: 10.1111/myc.13082. [Epub ahead of print]